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The dose-response relationship demonstrates that higher doses produce greater reductions in HbA1c and body weight, with clinical effects sustained over long-term treatment (Davies et al., 2021)
The monotherapy group had a difference in HbA1c % from baseline of 0.14% vs -0.9% in the combination group ( p = 0.007)
54 NAD + methylation Excess NAM that is not recycled is metabolized through two enzymatic systems and eventually excreted from the body
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