Am J Clin Nutr (1994) 60(6):8959
Further, once patients achieve their desired weight, therapies that are safer, cheaper, and/or more convenient to administer may be needed to help sustain the durability of the response
The GLP-1 Notch intracellular domain that is released by this cleavage transcriptionally regulates downstream targets, including the redundantly-acting genes lst-1 (lateral signaling target) and sygl-1 (synthetic Glp), to maintain a pool of GSCs within the PZ 13
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Others argue that as long as high-cost drugs exist, utilization management (UM) is necessary, and ePA is the ethical approach to implement UM transparently and fairly