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doi: 10.1126/science.1057110 67 SantosJ

Theres still a few hurdles to get over yet however This is certainly turning into an interesting 2026 for Novo Nordisk, especially after a bumpy start with that low expectation guidance

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However, despite their effectiveness, GLP-1 agonists are not without drawbackshigh cost, gastrointestinal side effects, long-term dependency, and concerns about sustainability once the drug is discontinued

So far, Novo is furthest ahead in developing an obesity pill

Option 2: Adding Metformin for More Robust Weight Loss For patients looking to accelerate their weight loss while on a GLP-1, adding Metformin can be an effective option