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doi:10.1038/s41569-023-00849-3 Lincoff A

If your pen has been left out of refrigeration for more than the manufacturers specified time (typically 21-28 days for opened pens), or exposed to direct heat, its safest to discard it and use a fresh supply to ensure youre getting the full therapeutic benefit

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Retrospective cohort studies using real-world data have indicated a neutral or reduced impact of GLP-1 RAs on suicidal ideation