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The next few years will determine whether this hope translates into real help for patients and families
For OGTT, mice were fasted for 6 hours starting at 8 AM and gavaged with a 20% D-(+)-glucose solution (Sigma Aldrich, G7021) at 1 g/kg body weight
The first generation of weight loss drugs focused on stimulant effects or blocking fat absorption, approaches that produced modest results with significant side effects and safety concerns
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