Adding GIPR co-agonism (as in tirzepatide and retatrutide) introduces additional Gs signalling from a second receptor type expressed on adipocytes, beta cells, and hypothalamic neurones
Patients with serious medical illnesses in whom caloric restriction could make the illness worse
Des risques faibles mais pouvant tre graves Dans de rares cas sont tablis les risques de : De pancratites aigus , D'affections hpato-biliaires (majoritairement des cholestases et lithiases biliaires), D'occlusions intestinales et de gastroparsies (1, 2)
[17] [18] Patients should be monitored for depression, suicidal thoughts or behavior, and any unusual changes in mood or behavior
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The doctor must be able to justify that it is in the patients best interest, and patients must have consented after being properly informed