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Diverse studies highlighted that simultaneous stimulation of GIP and GLP-1 receptors by agonists leads to more weight reduction than activation of either of these receptors in diet-induced obesity (Baggio and Drucker 2021

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Therefore, we selected exendin-4 as both a positive control and a combination partner for MOTS-c

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[33, 41, 42] In practice, the PEG-PLA nanoparticle solution (containing the peptide and Tween-20) is loaded into one sterile syringe, while the HPMC-C12 solution is loaded into a second