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Clinical observations in EPP patients support anti-inflammatory activity afamelanotide-treated subjects showed reduced severity of phototoxic inflammatory reactions beyond what eumelanin-mediated UV absorption alone would predict

Nox activity also contributes to glial inflammatory response in the brain 6

Reaching Natural Plateau Phase 2 trials showed the average participant reached plateau around week 43, with a range from week 36 to week 48 plus

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