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Four failure modes recur in the literature and in clinical practice
These effects are achieved through an increase in tumor-suppressor protein p53 levels and a reduction in kallikrein-related peptidase (KLK1, 2, 4, 9, and 10) gene expression
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Moreover, addition of Ca 2+ into nutrient solution improved the growth of Cu-treated seedling, by lowering the concentration of polyamines putrescine and increasing the levels of spermine and spermidine in the epicotyl of plants (Shen et al., 1998)
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This process consumes cellular methyl donors and, critically, prevents nicotinamide from being recycled into NAD+
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