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For type 2 diabetes (NICE NG28), GLP-1 receptor agonists are generally considered after metformin-based therapy has proven insufficient, and can be initiated in primary care according to local formularies and prescribing arrangements
Important regulatory context: The FDA has published communications addressing risks associated with some compounded GLP-1 products (for example, dosing errors and quality variability)
The long-term safety of these medications, including their potential associations with cancer risk and other uncommon events, warrants further investigation, the authors added
Specifically, the risk ratios for nausea ranged from 2.07 to 3.51 across different doses of tirzepatide, and from 2.45 to 2.84 for semaglutide (ESM Table 14)
Jun 8 2015;7(10):1369-1376
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