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The SUSTAIN (Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes) trial series began enrolling patients in 2012, ultimately encompassing multiple phase 3 trials with thousands of participants worldwide
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Dietary modifications should focus on: Reducing refined carbohydrates and added sugars, particularly fructose Limiting saturated fats whilst incorporating omega-3 fatty acids Increasing consumption of vegetables, whole grains, and lean proteins Following a Mediterranean-style diet, which evidence suggests benefits liver health Avoiding excessive caloric intake and processed foods Adhering to UK Chief Medical Officers' low-risk drinking guidelines (14 units per week or less, spread over 3 or more days)
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A parallel programme, REIMAGINE, is evaluating CagriSema specifically in type 2 diabetes
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