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At the same time, sustained receptor engagement may induce adaptive responses such as receptor desensitization, endocrine feedback suppression, or compensatory pathway activation

doi:10.3389/fnmol.2021.750810

The first involves gradually lowering your dose for example, stepping down from 2.4 mg to 1.7 mg of semaglutide over a four-week period

1,2 Promotes faster post-exercise recovery: Regular use may help decrease muscle damage and speed up recovery after intensive workouts

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Phase Maximum dose Weeks 17-20+ Weekly Dose 12 mg Notes Highest dose studied