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When these fusions are present, immunohistochemistry using antibodies directed toward the kinase domain demonstrates staining in all the melanocytes of the Spitz nevus, demonstrating that the Spitz nevus is a clonal proliferation of a melanocyte transformed by the fusion

Blood tests, like serum B12 levels and complete blood counts, are key to making these decisions

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More weight loss can add further benefits, but the main focus is usually long-term stability, not chasing a perfect number

Exposure also appeared to mitigate neurotoxic effects from chemotherapeutic compounds