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Comparative analyses of polyamine levels in human normal, benign, and malignant prostatic tissues reveal elevated spermine concentrations in normal and benign hyperplastic prostates, contrasting with reduced spermine levels in tumor tissues, particularly metastatic prostate cancer (65)

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Glutathione also participates in maintaining the redox state of protein thiol groups (sulfhydryl groups), which can influence protein structure, enzyme activity, and cellular signaling behavior under stress

Each experiment was performed at least three times, and the data are shown as the mean SD where applicable

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Mandal D, Baudin-Creuza V, Bhattacharyya A, Pathak S, Delaunay J, Kundu M, et al