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Rahn, S., Zimmermann, V., Viol, F., Knaack, H., Stemmer, K., Peters, L., Lenk, L., Ungefroren, H., Saur, D., Schfer, H., et al

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A landmark 68-week randomized controlled trial found that once-weekly semaglutide combined with lifestyle intervention produced a mean body weight reduction of approximately 14.9% compared to approximately 2.4% with placebo

Despite these advantages, affordability remains a major barrier

(Bateman et al., 29423816) N-acetylcysteine can be used in patients with a history of anaphylactoid reactions (although it may be wise to initiate the infusion at a lower dose and pre-treat with antihistamines)