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In summary, the most common symptoms of malignant schwannoma include a rapidly growing painful mass, nerve-related sensory or motor deficits, and systemic signs in advanced stages

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Rats possess thyroid C-cells that behave differently from human counterparts, and the doses used in animal models far exceeded typical human therapeutic ranges

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Histologic Grade: High mitotic index, necrosis, and cellular atypia correlate with more aggressive disease and worse survival