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Funding This work was supported by the Grants from the National Natural Science Foundation of China (31271445 and 31771582), the Natural Science Foundation of Guangdong Province of China (2025A1515012547), the Thousand, Hundred, and Ten Project of the Department of Education of Guangdong Province of China, the Yang Fan Project of Guangdong Province of China, and the Shantou Medical Health Science and Technology Plan (200624165260857)

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Sulforaphane (SFN) has demonstrated a favorable safety profile in multiple clinical studies

Ascorbate-derived imaging probes for hyperpolarized 13 C magnetic resonance spectroscopy and positron emission tomography have been used to study redox changes (antioxidant depletion and reactive oxygen species accumulation) in vivo

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