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In 2014, the Food and Drug Administration (FDA) first approved the use of GLP-1s for weight loss, and the results have been nothing short of transformative for many patients

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What Does Before and After Really Mean

In comparison to diet and exercise alone, GLP-1 drugs can cause people to lose more body fat, but also more muscle mass

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When combined, these drugs create overlapping cardiovascular stress: phentermine's stimulant effect paired with semaglutide's blood-pressure-modulating properties can lead to irregular heart rhythms, elevated blood pressure episodes, and increased risk of myocardial events