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18.2 Managing Gastrointestinal Side Effects Dietary adjustments, such as smaller meals and reduced fat intake, may alleviate gastrointestinal discomfort

At the same time, the "wear and tear" from daily life often increases

REWIND Investigators Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

General principles for subcutaneous injection such as ensuring the injection site is clean and following the device instructions carefully apply, but patients should not rely on guidance intended for other devices

We recommend incorporating at least 150 minutes of moderate-intensity exercise weeklysuch as brisk walking, cycling, or swimmingto support weight loss and enhance cardiovascular health

Most people begin to notice changes within the first one to two weeks , starting with reduced appetite and fewer cravings