Life Sciences, Indian Institute of Science (IISc) , Banglore, India The discovery of GLP-1 agonists reminds us that science not only treats diseases but it transforms lives. - Prasenjit Naskar Have you heard the recent news that surfaced regarding celebrities suddenly losing weight
Polycystic Ovary Syndrome (PCOS) - 5-10% of women 50% lower glutathione levels compared to women without PCOS 3-4x higher risk of preeclampsia 3x higher risk of gestational diabetes Critical concern: With 50% lower baseline glutathione, the "safe" dose is effectively cut in half IVF Conception - 2-5% of births (up to 6-8% in some countries) Women who conceive via IVF experience dramatic antioxidant depletion: 70% reduction in plasma antioxidant capacity 83% reduction in follicular fluid antioxidant capacity 50-100%+ increase in oxidative stress markers With over 5 million babies born via IVF globally, this represents a large high-risk population Gallbladder Dysfunction - 10% of pregnant women Up to 10% develop gallstones or biliary sludge Intrahepatic cholestasis: 0.4-10% of pregnancies CRITICAL: Fatal Outcomes Documented at Therapeutic Doses The first case of a pregnant woman with intrahepatic cholestasis who died from liver failure after taking THERAPEUTIC/NORMAL doses of acetaminophen was reported in 2022
Saxenda is used in addition to diet and exercise for long-term weight management in adults who are obese (BMI 30 kg/m 2 ) or overweight (BMI 27 kg/m 2 ) with other weight-related medical issues
Available at: [11] Tirzepatide and thyroid C-cell tumours (medullary thyroid carcinoma) in animal models
PFHxS, PFOA groupings) PAHs (anthracene, pyrene, benzo derivatives) 3 Endocrine disruptors now front and centre Multiple entries classified as: ED HH 1 ED ENV 1 This is a major signal for downstream regulatory pressure
An intriguing avenue of research is the combination of peptides and nuclear hormones, where the peptide serves to target the latter to specific tissues and intracellular sites of action to minimise adverse off-target tissue effects
