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However, it is crucial to emphasize that all data supporting this rationale derive from in vitro cell culture studies, in vivo animal experiments in rats and swine, and mechanistic extrapolation from established neuroendocrine physiology

Overall, GLP-1 RAs appear promising as adjunctive therapies for HS and psoriasis, especially in patients with coexisting metabolic disease

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Key takeaways Semaglutide is the active ingredient in Ozempic and Wegovy, and has been proven to help people lose weight in combination with lifestyle changes like diet and exercise

"There's been this real misconception that people are just taking Ozempic because they want to be skinny, and of course there are some people on TikTok doing that, but there are people out there that have really serious health conditions linked to their weight like heart disease, arthritis, fatty liver disease, PCOS [polycystic ovary syndrome], and they've been trying to work with their doctors to manage that." But Ms Petre said there was hope the development of Ozempic would also raise awareness about biological drivers of obesity, and correct the misconception that losing weight to improve health was just about willpower