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Choose clean, intact subcutaneous tissue within the abdomen, thigh, or upper arm

Abbreviations CAD: Coronary artery disease CANVAS: CANagliflozin cardioVascular Assessment Study CKD: Chronic kidney disease CLI: Critical limb ischaemia CVA: Cerebrovascular accident CVOT: Cardiovascular outcome trial DFU: Diabetic foot ulcer ESRD: End-stage renal disease GLP-1: Glucagon-like peptide-1 GLP1RA: Glucagon-like peptide-1 receptor agonist HTN: Hypertension LEAD: Lower extremity arterial disease LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results MACE: Major adverse cardiac events MALE: Major adverse limb events MI: Myocardial infarction NHI: National Health Insurance NHIRD: National Health Insurance Research Database PAD: Peripheral artery disease PSM: Propensity score matching PTA: Percutaneous transluminal angioplasty PY: Person-year SGLT2i: Sodiumglucose cotransporter 2 inhibitor SHR: Subdistribution HR STD: Standardised difference VTE: Venous thromboembolism References Fox CS, Golden SH, Anderson C et al (2015) Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: A scientific statement from the American Heart Association and the American Diabetes Association

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A study has shown that lixisenatide inhibits inflammation of RA in human FLSs by downregulating IL-6, IL-8 and TNF-, while also inhibiting cellular communication pathways including c-Jun N-terminal kinase (JNK) and NF-B [239]