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Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired
429 Another meta-analysis used indirect comparisons to rank the safety of oral anticoagulants by analyzing risks of major bleeding events in 23 randomized controlled trials involving 87,616 atrial fibrillation patients
high pharmacologic doses (1-3 g/day) can cause hypotension, insulin resistance, and hepatotoxicity
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