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The antioxidant properties of several natural compounds related to the activation of NRF-2 have been investigated [43], such as curcumin [97], KIOM-4, Resveratrol, Zinc, Berberine, L-arginine, oleanolic acid, vitamin D, among others, in animal cell cultures, with disagreeing results, mainly focused on the decrease of OS or the increase of elements of antioxidant response through NRF-2 [43]

74 The group added one or two oxygen atoms on the hydroxyl chain of the NBD bone, forming two NBDHEX analogs, MC3181 and MC3165, that were able to display higher selectivity and better external activity by forming a stable -complex with the active site of GST

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