A novel furocoumarin derivative, 5-((diethylamino)me-13 thyl)-3-phenyl-7H-furo 3,2-g chromen-7-one upregulates melanin synthesis via the activation of cAMP/PKA and MAPKs signal pathway: in vitro and in vivo study
doi: 10.3389/fphar.2014.00181 Received 31 May 2014 Accepted 16 July 2014 Published 11 August 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Marc Diederich, Laboratoire de Biologie Molculaire et Cellulaire du Cancer, Hpital Kirchberg, Luxembourg
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Scores on the Three-Factor Eating Questionnaire (TFEQ-R18) improved in all treatment groups, with Cagrilintide producing greater improvements than placebo in specific domains: cognitive restraint, notably at 1.2 mg and 4.5 mg, emotional eating notably at 0.3 mg and 2.4 mg, and uncontrolled eating notably at 1.24.5 mg