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Proc Natl Acad Sci USA 1991;88:36336

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The amphiphilic compound N-acetil--D-glucosaminil-PEG900-docosanato (C22PEG900GlcNAc 1509 g/mol) was synthesized by esterification of N3-PEG900-OH with docosanoic acid, followed by a click chemistry reaction with a modified carbohydrate, as described in the literature

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The rat dose (20 mg/kg) was calculated using the human-equivalent dose conversion formula, resulting in a dosage approximately 6.3 times the human dose, but not exceeding 500 mg per day

Regular exercise can also help to keep stress at bay by increasing endorphin (feel good hormone) production, which helps to improve mood and positively impact the cardiovascular system