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Thus, semaglutide is formulated for once-weekly injection
GLP-1RAs aid in weight loss by regulating the gut-brain axis and interacting with leptin, while weight loss can alleviate the harmful effects of obesity on the body, particularly in knee OA, by reducing joint loading and inflammation
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Muller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E et al
Taking it earlier may increase the risk of side effects or affect the medication's effectiveness
Study has demonstrated that GSDMD mediates the shift of tubular cells from apoptosis to pyroptosis in TLR4-regulated diabetic tubular damage, suggesting that GSDMD activation promotes the conversion from non-inflammatory apoptosis to inflammatory pyroptosis (227)
