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One notable difference is that tirzepatide is a dual-agonist (GLP-1 and GIP) while retatrutide is a triple-agonist (GLP-1, GIP, and glucagon)

This article shows that activation of hypothalamic GIPR cells/neurons decreases food intake

Combining elegance and style, it was designed to with modern man in mind

11 However, human data remains largely inconclusive, necessitating additional research to establish efficacy and optimal dosage

Bifunctional PEGylated exenatide-amylinomimetic hybrids to treat metabolic disorders: an example of long-acting dual hormonal therapeutics

Adao DMT, Ching C, Fish JE, Simmons CA, Billia F