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10.1016/j.ajpath.2019.06.012 40 MizushimaN.KomatsuM

As mentioned above, ferroptosis could be induced to exert anti-tumor functions via signaling pathway modulation, non-coding RNA expression, DNA methylation, histone modification, CSCs, microenvironment remodeling, and so on

Although the human body naturally produces glutathione, factors such as age and poor diet can cause the levels of this essential antioxidant to decrease

Consistent with the results of the risk analysis, a cross-sectional study [10] and a longitudinal, retrospective study [14] also found that elevated serum ferritin and reduced serum transferrin were associated with DM and diabetic end-stage renal disease

Biochemistry 30 , 613619 (1991)