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The safety and efficacy of once daily insulin glargine administered pre-breakfast or at bedtime were also evaluated in a randomized, active-controlled clinical study (Study I, n = 697) in patients with type 2 diabetes not adequately controlled on oral antidiabetic therapy

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Glu205 makes salt bridge with Arg125, which in turn is hydrogen-bonded to the C-terminal carboxylate group of Diprotin A