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Specifically, GLP-1s can increase the risk of hypoglycemia (low blood sugar) and SGLT-2s can raise the risk of a serious, life-threatening complication called diabetic ketoacidosis (DKA)
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The trial demonstrated dose-dependent weight loss, with participants receiving 12 mg achieving a mean body weight reduction of approximately 24% over 48 weeks a result that has attracted considerable scientific and public interest
Among those with insurance, 30% reported that affording their share of GLP-1 costs was somewhat difficult, and 25% reported that it was very difficult
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The treatment for 24 weeks led to substantial reductions in liver fat content across all dosage levels, with a mean relative change from baseline of up to -82.4% for the highest dose
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