In practical terms, this means that metabolic health not just reproductive anatomy plays a significant role in male fertility
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Spermatozoa are vulnerable to ROS because their plasma membrane and cytoplasm contain large amounts of polyunsaturated fatty acids (Alvarez & Storey, 1995), resulting in a decrease in sperm motility, presumably by a rapid loss of intracellular ATP, causing axonemal damage (de Lamirande & Gagnon, 1992), a decrease in sperm viability and an increase in mid-piece morphology defects, with deleterious effects on sperm capacitation and acrosome reaction
Acknowledgements The authors thank the Cloning, Cell Expression, Protein Purification and Assay Development Core Facilities of iHuman Institute for their support
A hearing evaluation, properly fitted hearing aids, cataract care, vision correction, and fall-risk reduction may have more practical cognitive relevance for some patients than chasing the newest supplement or protocol
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