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Biochemistry 2007;46:5830-40

Constipation or diarrhea, often alternating

The injection route provides direct delivery of the peptide into the bloodstream, making it less susceptible to outside variables such as nasal congestion or mucosal integrity

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Scientific Data: GI Side Effects: A large phase 3 study found that semaglutide had a lower incidence of severe gastrointestinal side effects compared to liraglutide

Vision changes: Diabetic patients may experience worsening diabetic retinopathy during rapid blood sugar improvements