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Furthermore, active GLP-1 is rapidly degraded by dipeptidyl peptidase IV (DPP-IV) (1215)

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Phase 2 data have already shown up to 12.3 percent weight loss in non diabetic patients, which makes the monthly dosing concept clinically and commercially important if durability, tolerability and adherence can hold up in larger studies

The dose escalation phase (weeks 416, depending on the specific medication) involves gradually increasing the dose according to the prescribed schedule

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