Too bad it has become so hard to get here."
Reduced FH enzyme activity leads to the accumulation of the cellular level of fumarate, and fumarate can undergo a reaction with cysteine residues of proteins, which is called succination (Pollard et al., 2005)
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Delivery of dual drug loaded lipid based nanoparticles across the bloodbrain barrier impart enhanced neuroprotection in a rotenone induced mouse model of Parkinsons disease
This creates a dangerous bottleneck where highly toxic Phase I intermediates accumulate in the liver, leading to systemic toxicity, severe hepatic inflammation, and a cascading failure of the body's natural waste-removal systems
In keeping with this observation, here we unveil a crucial role of GSH in lipid production, as the synthesis of GSH, specifically in the liver, is required for sustaining physiological circulating triglyceride levels (an important energy source) and adipose tissue homeostasis under standard dietary regimen
