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Permeability was calculated as follows: where P app represents the Caco-2 permeability, dQ/dt refers to the amount of drug in the basolateral side by time (mol/s), A refers to the area of the Transwell plate (cm 2 ), and C 0 refers to the initial concentration of drug on the apical side (mol/mL)

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[6] Ipamorelin and Diabetes Studies in murine models of diabetes have suggested an efficacy of Ipamorelin in promoting insulin release from islet cells of the pancreas

Treatment with the two highest KBP-089 doses (1.25 and 2.5 g/kg) as well as their combinations with liraglutide resulted in a significant reduction in food efficiency compared with vehicle