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As well as being a primary precursor of (-)-jasmonic acid, (+)-12-oxo-phytodienoic acid ( cis -OPDA) is reported to regulate growth processes and certain jasmonate-responsive genes in plants (although some doubts have been expressed), and it induces and fine-tunes defence and stress responses (see below), as does a C 20 analogue of OPDA detected in a liverwort
Studies also found that persistent low-grade inflammatory activation is related to the severity of depressive symptoms and the probability of treatment response (57)
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Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treated with fumaric acid esters
*Nutrients*, 11(10), 2412
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