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In the catalytic activation of the apoptotic cascade, caspase family proteases and BCL-2 family proteins such as Bcl-2-associated X (BAX) and B-cell lymphoma 2 (Bcl-2) play an important role (Pistritto et al., 2016)

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J Allergy Clin Immunol 118 : 12181225 Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA, Severe Asthma Research Program 2009 Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress