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Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11

Receptor downregulation after 810 weeks of continuous use necessitates cycling protocols (8 weeks on, 4 weeks off) to maintain response magnitude

doi: 10.1007/s00125-016-3929-0 79 ChenHJLeeYJHuangCCYenYCLinYF

doi: 10.1111/bph.15603, 13 BroideE.BlochO.Ben-YehudahG.CantrellD.ShirinH.RapoportM

Dosing considerations for a theoretical combined protocol No established protocol exists for combining tesamorelin and retatrutide