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Rapid degradation, poor oral availability, difficult transportation through cell membranes, nonselective receptor binding, and challenging multistep preparation are the major limitations of peptides as active pharmaceutical ingredients
This picture can also be caused by folate deficiency
Lnu V et al
Treating Alzheimers disease with monoclonal antibodies: current status and outlook for the future
10.1245/ASO.2006.03.060 126 ZhuC.IkemotoT.UtsunomiyaT.YamadaS.MorineY.ImuraS.et al (2014)
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