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At the molecular level, central or peripheral insulin resistance can result from reduced insulin receptor expression, decreased binding affinity, and disruption of downstream signaling pathways (Tatar et al., 2003)
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I have not been able to do this with heavy exercise or dieting
This can happen for various reasons, such as when a doctor believes the medication may benefit a particular patient's condition, even though it hasn't been officially tested and approved for that specific use
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