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Nevertheless, patients using insulin or sulfonylureas may require dose adjustments when initiating potent incretin-based therapy because improved glycemia and reduced caloric intake can increase hypoglycemia risk when combined with therapies that independently lower glucose

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TGF-beta1 down-regulation in the mediobasal hypothalamus attenuates hypothalamic inflammation and protects against diet-induced obesity

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The broad success of the fantasy comedy Big (1988) established Hanks as a major Hollywood talent, both as a box office draw and within the industry as an actor

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This process induces lactylation of P53 and promotes tumor development by regulating mechanisms such as the Hippo pathway [79, 80]

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