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53% homology to human GLP-1

11 Importantly, structural modifications to GLP-1RAs can prolong their half-life to 5-7 days compared to the 1-5 minute long half-life of endogenous GLP-1

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At the indicated time (20 min and 60 min), an aliquot of 70 L was removed from each experimental reaction and pipetting into 175 L of acetonitrile at 0 C to quench the reaction ( t = 0 min was determined using the reaction without pancreatin)

This potential effect on inflammation has led some scientists to wonder if semaglutide might help people with inflammatory diseases such as RA