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The risk profile changes when tesamorelin is combined with retatrutide, which through its metabolic effects could alter the hormonal environment in ways that affect IGF-1 clearance or activity

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However, its important to note that both Semaglutide GLP-1 and Liraglutide can cause gastrointestinal side effects, with a slightly higher incidence in patients taking Semaglutide GLP-1

GLP-1 medications often need to be taken long-term for weight loss