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Researchers found a significant 21% increase in serum IGF binding protein-1a protein that impacts IGF-1 activityamong those that reduced calories

Salehpour, S., Hosseini, S., Nazari, L., Hosseini, M., & Saharkhiz, N

For those brave enough to read on, I went back to my undergraduate days of biochemistry, and pulled a couple of papers out 2,4

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Cycling allows receptors to reset, maintaining sensitivity for subsequent cycles