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Important limitations of the current evidence include: Most trials have been relatively small and of short duration (typically 816 weeks) Study quality varies, with some trials lacking robust blinding or having high dropout rates Publication bias may exist, with negative studies less likely to be published Long-term safety and efficacy data beyond three months are scarce Few studies have been conducted in Western populations or UK healthcare settings The National Institute for Health and Care Excellence (NICE) does not include berberine in its guidelines for diabetes management (NG28), reflecting the lack of sufficient high-quality evidence to support its routine use

Methods Mice were exposed to CS for 5 h after which they were rested in filtered air for up to 16 h

Jin J, Byun JK, Choi YK, Park KG

Those with active skin infections or open wounds

Have a history of diabetic retinopathy

Patients who want improved body composition without GLP-1 side effects are often very well matched