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Whilst many symptoms improve with appropriate B12 treatment, not all resolve completely, especially if neurological damage was severe or prolonged before treatment commenced
Glutathione: Physiological and clinical relevance
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severe thiamine deficiency, while rare, can cause Wernickes encephalopathy in hyperemesis gravidarum, and inadequate B is associated with anemia and neurologic issues in the newborn
Effects of alpha-tocopherol and beta-carotene supplementation on cancer incidence and mortality: 18-year postintervention follow-up of the Alpha-tocopherol, Beta-carotene Cancer Prevention Study