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Disease severity was categorized as 1 or 2 according to the WHO clinical ordinal scale 19
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Post-surgical recovery affecting multiple tissue types, chronic widespread inflammation, and patients whose primary complaint is global stiffness and reduced range of motion that has not improved with localized treatment all fit the TB-500 indication
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The class is not uniformly effective, even topically: a controlled irradiated-rat study found no benefit of topical GHK-Cu on flap ischaemia, vessel number/area or VEGF versus control a clean negative that tempers enthusiasm for the whole class [11]
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