Anecdotally, some people who switched from semaglutide to tirzepatide report that their appetite, which had started returning somewhat on semaglutide, decreased again on tirzepatide
As the result, GLP-1 analogs significantly reduced visceral fat and showed a trend to reduce subcutaneous fat
Ongoing therapy also provides metabolic benefits beyond appetite suppression, including improved insulin function and reduced inflammation that supports long-term health outcomes
"Our priority is to ensure that patients have a safe and positive experience with our FDA-approved semaglutide medicines, and these actions are a direct reflection of that focus," Doug Langa, executive vice president of North America operations and president of Novo Nordisk, said in the press release announcing the lawsuit
All four carry 503A compounding status of Under Review as of 2026
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