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The discrepancy between, on the one hand, repeated findings of an association between indices of relative vitamin B12 deficiency and cognitive impairment and, on the other hand, the lack of substantial benefit in therapeutic trials of B vitamin supplementation is not understood

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B vitamins are often prescribed together because deficiency of one B vitamin usually signals that others are deficient

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Fatal hypokalemia may occur when severe megaloblastic anemia is treated intensively with vitamin B12, as a result of increased erythrocyte potassium requirements